103Pd radioactive stent inhibits biliary duct restenosis and reduces smooth muscle actin expression during duct healing in dogs

This study was designed to assess the expression of smooth muscle actin (SMA) in the healing process after implanting a (103)Pd radioactive stent in the biliary duct, and to discuss the function and significance of this stent in preventing biliary stricture formation. A model of biliary injury in do...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2006-11, Vol.5 (4), p.595-598
Main Authors: He, Gui-Jin, Gao, Qin-Yi, Xu, Shu-He, Gao, Hong, Jiang, Tao, Dai, Xian-Wei, Ma, Kai
Format: Article
Language:English
Subjects:
103Pd
actin
Actins - metabolism
Animals
Bile Ducts, Extrahepatic - metabolism
Bile Ducts, Extrahepatic - pathology
Bile Ducts, Extrahepatic - surgery
biliary
Constriction, Pathologic - pathology
Constriction, Pathologic - prevention & control
Dogs
duct
healing
Male
muscle
Muscle, Smooth - metabolism
Palladium
radioactive
Radioisotopes
smooth
stent
Stents
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Summary:This study was designed to assess the expression of smooth muscle actin (SMA) in the healing process after implanting a (103)Pd radioactive stent in the biliary duct, and to discuss the function and significance of this stent in preventing biliary stricture formation. A model of biliary injury in dogs was made and then a (103)Pd radioactive stent was positioned in the biliary duct. The expression and distribution of SMA were assessed in the anastomotic tissue 30 days after implantation of the stent. SMA expression was less in the (103)Pd stent group than in the ordinary stent group. The (103)Pd stent inhibited scar contracture and anastomotic stenosis. The (103)Pd stent can reduce the expression of SMA in the healing process and inhibit scar contracture and anastomotic stenosis in the dog biliary duct.
ISSN:1499-3872