Acquired von Willebrand's syndrome resulting from untreated hypothyroidism in two prepubertal girls

Acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder associated with a number of different diseases, including hypothyroidism. We describe two prepubertal girls with AvWS and undiagnosed hypothyroidism due to thyroiditis Hashimoto. The patients had neither family history nor symptoms...

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Bibliographic Details
Published in:Haemophilia : the official journal of the World Federation of Hemophilia 2006-11, Vol.12 (6), p.687-689
Main Authors: GALLI‐TSINOPOULOU, A., STYLIANOU, C., PAPAIOANNOU, G., NOUSIA‐ARVANITAKIS, S.
Format: Article
Language:English
Subjects:
Acquired von Willebrand's syndrome
Child
children
Female
Hashimoto Disease - complications
Hashimoto Disease - diagnosis
Humans
hypothyroidism
Hypothyroidism - complications
Hypothyroidism - diagnosis
thyroiditis Hashimoto
von Willebrand Diseases - diagnosis
von Willebrand Diseases - etiology
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Summary:Acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder associated with a number of different diseases, including hypothyroidism. We describe two prepubertal girls with AvWS and undiagnosed hypothyroidism due to thyroiditis Hashimoto. The patients had neither family history nor symptoms of bleeding disorders. Substitution therapy with levothyroxine led to normalization of the coagulation parameters. We report these cases in order to raise awareness among paediatricians so that the AvWS should be suspected and searched for with the appropriate laboratary tests in all cases of hypothyroidism. Moreover, patients with bleeding diathesis of unknown origin should also be investigated for hypothyroidism.
ISSN:1351-8216
1365-2516
DOI:10.1111/j.1365-2516.2006.01355.x