The in vitro effect of a lyophilized extract of wine obtained from Jacquez grapes on human chondrocytes

The present work was aimed at evaluating the in vitro effects of a lyophilized extract of wine (JW-E) obtained from Jacquez grapes ( Vitis aestivalis-cinerea×Vitis vinifera grapes) on the production of key molecules released in inflammatory disease utilising interleukin-1 β (IL-1 β) activated chondr...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2006-07, Vol.13 (7), p.522-526
Main Authors: Panico, A.M., Cardile, V., Avondo, S., Garufi, F., Gentile, B., Puglia, C., Bonina, F., Santagati, N.A., Ronsisvalle, G.
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Cartilage, Articular - cytology
Cell research
Cells, Cultured
Chondrocytes
Chondrocytes - drug effects
Dinoprostone - metabolism
Drug therapy
Fruit
Humans
Inflammation - drug therapy
Interleukin-1 - pharmacology
Jacquez grapes wine (JW-E)
Nitric Oxide - metabolism
Osteoarthritis
Osteochondritis - drug therapy
PGE 2
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Reactive Oxygen Species - metabolism
ROS
Vitis
Wine
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Summary:The present work was aimed at evaluating the in vitro effects of a lyophilized extract of wine (JW-E) obtained from Jacquez grapes ( Vitis aestivalis-cinerea×Vitis vinifera grapes) on the production of key molecules released in inflammatory disease utilising interleukin-1 β (IL-1 β) activated chondrocytes. The extract contains large amounts of phenolic components, in particular some flavonoids (flavan-3-ols, also known as catechins) and proanthocyanidins, as hydroxycinnamic acids and anthocyanins, that possess several biological features such as antiinflammatory and antioxidant effects and a “radical scavenger” activity too. In this study, we assayed the effect of JW-E on the production of key molecules released during chronic inflammatory events as nitric oxide (NO), prostaglandins E 2 (PGE 2) and reactive oxygen species (ROS) in human chondrocytes culture, stimulated with proinflammatory cytokine interleukin-1 β. The JW-E proved to possess good ability against the harmfull effects of IL-1 β. Our data showed the protective effects of JW-E in cartilage alteration, that appears greater than that elicited by indomethacin, a not steroidal antiinflammatory drug (NSAID), commonly employed in joint diseases.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2005.06.009