Plasmodium rhoptries: how things went pear-shaped

Plasmodium parasites have three sets of specialised secretory organelles at the apical end of their invasive forms – rhoptries, micronemes and dense granules. The contents of these organelles are responsible for or contribute to host cell invasion and modification, and at least four apical proteins...

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Bibliographic Details
Published in:Trends in parasitology 2006-06, Vol.22 (6), p.269-276
Main Authors: Kats, Lev M., Black, Casilda G., Proellocks, Nicholas I., Coppel, Ross L.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Erythrocytes - parasitology
Host-Parasite Interactions
Human protozoal diseases
Humans
Infectious diseases
Malaria
Medical sciences
Organelles - physiology
Organelles - ultrastructure
Parasitic diseases
Plasmodium
Plasmodium - pathogenicity
Plasmodium - physiology
Plasmodium - ultrastructure
Protozoal diseases
Protozoan Proteins - metabolism
Protozoan Proteins - physiology
Protozoan Proteins - ultrastructure
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Summary:Plasmodium parasites have three sets of specialised secretory organelles at the apical end of their invasive forms – rhoptries, micronemes and dense granules. The contents of these organelles are responsible for or contribute to host cell invasion and modification, and at least four apical proteins are leading vaccine candidates. Given the unusual nature of Plasmodium invasion, it is not surprising that unique proteins are involved in this process. Nowhere is this more evident than in rhoptries. We have collated data from several recent studies to compile a rhoptry proteome. Discussion is focussed here on rhoptry content and function.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2006.04.001