Karyomegalic tubulointerstitial nephritis—A case report

Karyomegalic tubulointerstitial nephritis is a rare disease of uncertain etiology, which leads to progressive renal failure. Here, we report on a 39-year-old patient who presented with asymptomatic progressive decline of renal function. Two sequential renal biopsies demonstrated chronic tubulointers...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2006-01, Vol.202 (7), p.555-559
Main Authors: Baba, Füsun, Nanovic, Lisa, Jaffery, Jonathan B., Friedl, Andreas
Format: Article
Language:English
Subjects:
Adult
Biopsy
Cell Nucleus - pathology
Cell Nucleus - ultrastructure
Cell Proliferation
Chronic Disease
Humans
Interstitial nephritis
Karyomegalic tubulointerstitial nephritis
Kidney Tubules, Proximal - pathology
Male
Nephritis, Interstitial - etiology
Nephritis, Interstitial - pathology
Nephritis, Interstitial - physiopathology
Systemic karyomegaly
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Description
Summary:Karyomegalic tubulointerstitial nephritis is a rare disease of uncertain etiology, which leads to progressive renal failure. Here, we report on a 39-year-old patient who presented with asymptomatic progressive decline of renal function. Two sequential renal biopsies demonstrated chronic tubulointerstitial nephritis with bizarre and dramatic enlargement of proximal tubule epithelial cell nuclei – the hallmark of karyomegalic nephritis. Clinical and pathologic findings of this case are discussed in light of the available literature. The morphologic changes in this disease are highly characteristic if the pathologist is aware of this entity.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2006.02.004