Synthesis and Cytotoxicity of Novel Sansalvamide A Derivatives

Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combinatorial-type strategy that permits elucidation of the amino acid role in t...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2005-08, Vol.7 (16), p.3481-3484
Main Authors: Carroll, Chris L, Johnston, Jennifer V. C, Kekec, Ahmet, Brown, Joseph D, Parry, Emily, Cajica, Julia, Medina, Irene, Cook, Kristina M, Corral, Ricardo, Pan, Po-Shen, McAlpine, Shelli R
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Depsipeptides - chemical synthesis
Depsipeptides - chemistry
Depsipeptides - pharmacology
Drug Screening Assays, Antitumor
Fusarium - chemistry
Humans
Molecular Structure
Structure-Activity Relationship
Tumor Cells, Cultured
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combinatorial-type strategy that permits elucidation of the amino acid role in the cytotoxicity, and they lay the groundwork for development of new anticancer agents.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol051161g