ACE ID genotype and the muscle strength and size response to unilateral resistance training

To examine associations among the angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism and the response to a 12-wk (2 d.wk) unilateral, upper-arm resistance training (RT) program in the trained (T, nondominant) and untrained (UT, dominant) arms. Subjects were 631 (mean+/-SEM...

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Published in:Medicine and science in sports and exercise 2006-06, Vol.38 (6), p.1074-1081
Main Authors: PESCATELLO, Linda S, KOSTEK, Matthew A, VISICH, Paul S, ZOELLER, Robert F, DEVANEY, Joseph M, HOFFMAN, Eric P, GORDISH-DRESSMAN, Heather, THOMPSON, Paul D, SEIP, Richard L, PRICE, Thomas B, ANGELOPOULOS, Theodore J, CLARKSON, Priscilla M, GORDON, Paul M, MOYNA, Niall M
Format: Article
Language:English
Subjects:
Adult
Anatomy, Cross-Sectional
Biological and medical sciences
Body Mass Index
DNA Transposable Elements - genetics
Female
Fundamental and applied biological sciences. Psychology
Gene Deletion
Gene Frequency
Genotype
Humans
Isometric Contraction - physiology
Magnetic Resonance Imaging
Male
Muscle Contraction - physiology
Muscle, Skeletal - anatomy & histology
Muscle, Skeletal - physiology
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Space life sciences
Upper Extremity - physiology
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
Weight Lifting - physiology
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Summary:To examine associations among the angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism and the response to a 12-wk (2 d.wk) unilateral, upper-arm resistance training (RT) program in the trained (T, nondominant) and untrained (UT, dominant) arms. Subjects were 631 (mean+/-SEM, 24.2+/-0.2 yr) white (80%) men (42%) and women (58%). The ACE ID genotype was in Hardy-Weinberg equilibrium with frequencies of 23.1, 46.1, and 30.8% for ACE II, ID, and DD, respectively (chi=1.688, P=0.430). Maximum voluntary contraction (MVC) and one-repetition maximum (1RM) assessed peak elbow flexor muscle strength. Magnetic resonance imaging measured biceps muscle cross-sectional area (CSA). Multiple variable and repeated-measures ANCOVA tested whether muscle strength and size differed at baseline and pre- to post-RT among T and UT and ACE ID genotype. Baseline muscle strength and size were greater in UT than T (Por= 0.05). In T, MVC increases were greater for ACE II/ID (22%) than DD (17%) (Por= 0.05). In UT, MVC increased among ACE II/ID (7%) (Por= 0.05). In UT, 1RM (11%) and CSA (2%) increases were greater for ACE DD/ID than ACE II (1RM, 7%; CSA, -0.1%) (P
ISSN:0195-9131
1530-0315
DOI:10.1249/01.mss.0000222835.28273.80