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Breast Density and Parenchymal Patterns as Markers of Breast Cancer Risk: A Meta-analysis
Mammographic features are associated with breast cancer risk, but estimates of the strength of the association vary markedly between studies, and it is uncertain whether the association is modified by other risk factors. We conducted a systematic review and meta-analysis of publications on mammograp...
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Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2006-06, Vol.15 (6), p.1159-1169 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Mammographic features are associated with breast cancer risk, but estimates of the strength of the association vary markedly
between studies, and it is uncertain whether the association is modified by other risk factors. We conducted a systematic
review and meta-analysis of publications on mammographic patterns in relation to breast cancer risk. Random effects models
were used to combine study-specific relative risks. Aggregate data for >14,000 cases and 226,000 noncases from 42 studies
were included. Associations were consistent in studies conducted in the general population but were highly heterogeneous in
symptomatic populations. They were much stronger for percentage density than for Wolfe grade or Breast Imaging Reporting and
Data System classification and were 20% to 30% stronger in studies of incident than of prevalent cancer. No differences were
observed by age/menopausal status at mammography or by ethnicity. For percentage density measured using prediagnostic mammograms,
combined relative risks of incident breast cancer in the general population were 1.79 (95% confidence interval, 1.48-2.16),
2.11 (1.70-2.63), 2.92 (2.49-3.42), and 4.64 (3.64-5.91) for categories 5% to 24%, 25% to 49%, 50% to 74%, and ≥75% relative
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ISSN: | 1055-9965 1538-7755 |
DOI: | 10.1158/1055-9965.EPI-06-0034 |