Obtaining and screening compound collections: a user's guide and a call to chemists

Advances in genetics, proteomics and cell biology over the past 20 years have unearthed a multitude of potential macromolecular targets for the selective treatment of disease. The challenge remains to find appropriate small molecule ligands for these proteins (or nucleic acids), and to use these lig...

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Bibliographic Details
Published in:Current opinion in chemical biology 2006-06, Vol.10 (3), p.213-218
Main Author: Hergenrother, Paul J
Format: Article
Language:English
Subjects:
Combinatorial Chemistry Techniques
Database Management Systems
Drug Approval
United States
United States Food and Drug Administration
User-Computer Interface
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Summary:Advances in genetics, proteomics and cell biology over the past 20 years have unearthed a multitude of potential macromolecular targets for the selective treatment of disease. The challenge remains to find appropriate small molecule ligands for these proteins (or nucleic acids), and to use these ligands to validate novel disease targets. The advent of low-cost instrumentation has made industrial-style high-throughput screening possible in academic settings. Unfortunately for many, access to large collections of compounds is still limited and limiting. This article is aimed at the user who has an interest in compound screening but does not have ready access to large collections of small molecules. High-throughput screening need not be the exclusive domain of institutions and centers with vast resources and NIH Roadmap-funded compound repositories. As it turns out, many of the most interesting compounds are probably within arm's reach, in our laboratory freezers and in those of our colleagues.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2006.04.005