Novel subtypes (subgenotypes) of hepatitis B virus genotypes B and C among chronic liver disease patients in the Philippines

1 Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan 2 Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya...

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Published in:Journal of general virology 2006-07, Vol.87 (7), p.1873-1882
Main Authors: Sakamoto, Tomoyuki, Tanaka, Yasuhito, Orito, Etsuro, Co, Jonard, Clavio, Joseph, Sugauchi, Fuminaka, Ito, Kiyoaki, Ozasa, Atsushi, Quino, Alvin, Ueda, Ryuzo, Sollano, Jose, Mizokami, Masashi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Hepatocellular - virology
Enhancer Elements, Genetic
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genome, Viral
Genotype
Hepatitis B virus
Hepatitis B virus - classification
Hepatitis B virus - genetics
Hepatitis B, Chronic - virology
Humans
Liver Cirrhosis - virology
Liver Neoplasms - virology
Microbiology
Miscellaneous
Molecular Sequence Data
Mutation
Philippines
Phylogeny
Promoter Regions, Genetic
Viral Core Proteins - genetics
Virology
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Summary:1 Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan 2 Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan 3 Section of Gastroenterology, University of Santo Tomas, Manila, Philippines Correspondence Masashi Mizokami mizokami{at}med.nagoya-cu.ac.jp Several hepatitis B virus (HBV) subtypes (subgenotypes), HBV/Aa (A1 : Asia/Africa), Ae (A2 : Europe), Bj (B1 : Japan) and Ba (B2 : Asia), have been reported with respect to clinical differences between patients infected with these subtypes (subgenotypes). HBV genotype distribution among patients with chronic liver diseases was investigated in the Philippines, where such studies have not been carried out previously. One hundred sera were obtained from such patients, consisting of 32 chronic hepatitis (CH), 37 cirrhosis and 31 hepatocellular carcinoma (HCC) patients. Nine complete genomes and 100 core promoter/precore genes of HBV were sequenced directly. Phylogenetic analyses revealed 51 HBV/A (Aa/A1), 22 HBV/B and 27 HBV/C strains. Interestingly, most HBV/C strains in the Philippines formed a specific cluster distinct from previous HBV/C strains (C1–4), indicating a novel subtype (subgenotype), HBV/C5. Moreover, most HBV/B strains fell within the specific cluster of the HBV/B subtype (subgenotype) B5, with viral characteristics of HBV/Ba (B2) carrying a recombination with HBV/C over the precore and core genes. Of the three genotypes, HBV/B and HBV/C were significantly more prevalent than HBV/A in cirrhosis and HCC patients ( P
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.81714-0