The quality of chemotherapy and its quality assurance

Assessment of the quality of chemotherapy care and its quality assurance in clinical trials and daily practice. Using Medline, literature was searched combining the following words: quality assurance or quality of care, combined with anti-neoplastic agents. The bibliography of each article was revie...

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Bibliographic Details
Published in:European journal of surgical oncology 2005-08, Vol.31 (6), p.656-666
Main Authors: Ottevanger, P.B., De Mulder, P.H.M.
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chemotherapy
Clinical Trials as Topic
Daily practice
Humans
Neoplasms - drug therapy
Quality
Quality assurance
Quality Assurance, Health Care
Quality of Health Care
Risk Factors
Treatment Outcome
Trials
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Summary:Assessment of the quality of chemotherapy care and its quality assurance in clinical trials and daily practice. Using Medline, literature was searched combining the following words: quality assurance or quality of care, combined with anti-neoplastic agents. The bibliography of each article was reviewed for additional literature. Those reports in English, French, German or Dutch focusing quality assurance or quality of care and chemotherapy were selected. One hundred and five articles were selected by Medline and after review and adding of additional literature 53 articles remained. In clinical trials information on quality of chemotherapy is sparse. Different cooperative groups reported on suboptimal dosing, suboptimal registration of chemotherapy and several trials indicated that suboptimal dosing led to impaired outcome. Most quality assurance activities in clinical trials are concerned with audit and feedback and on-site visits. In daily practice the quality of chemotherapy is mostly impaired by the fact that it is not given although indicated and if it is given non-evidence based chemotherapy or administration schedules and reduced dose intensity decrease the quality of care. Especially, age, comorbidity and socio-economic status reduce the chance of receiving good quality of care regarding chemotherapy. Activities mostly used for quality assurance are generation of guidelines, specialisation and multidisciplinary care. Most quality assurance activities in clinical trials and daily practice are directed to structure and process parameters. More evidence that quality of care is related to outcome should be sought. Quality assurance in daily practice should aim at guideline implementation, specialisation and multidisciplinary care and should pay attention especially to the older patients, patients with comorbidity and patients from lower socio-economic classes.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2005.02.019