Clomiphene citrate challenge test predicts outcome of intrauterine insemination in women aged under 37 years

The clomiphene citrate challenge test is a tool to predict ovarian reserve and fertility. It has mainly been used as a predictor of success of IVF/intracytoplasmic sperm injection (ICSI) cycles. Infertile young women with diminished ovarian reserve have a worse prognosis than women with adequate ova...

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Bibliographic Details
Published in:Reproductive biomedicine online 2006-04, Vol.12 (4), p.423-427
Main Authors: Magendzo, Amiram, Schwarze, Juan-Enrique, de la Vega, Claudia Diaz, Altieri, Elena, Zegers-Hochschild, Fernando, Balmaceda, Jose P
Format: Article
Language:English
Subjects:
Adult
Age Factors
Clomiphene - administration & dosage
clomiphene citrate challenge test
Counseling
Female
Fertility Agents, Female - administration & dosage
Humans
Infertility, Female - diagnosis
Insemination, Artificial
IUI
ovarian reserve
Predictive Value of Tests
Pregnancy
Pregnancy Rate
Prognosis
young
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Summary:The clomiphene citrate challenge test is a tool to predict ovarian reserve and fertility. It has mainly been used as a predictor of success of IVF/intracytoplasmic sperm injection (ICSI) cycles. Infertile young women with diminished ovarian reserve have a worse prognosis than women with adequate ovarian reserve attempting IVF/ICSI cycles. Nothing is known regarding the outcome of young women with diminished ovarian reserve undergoing low-complexity assisted reproductive treatment such as ovulation induction plus intrauterine insemination (IUI). This study included all women under 37 years who consulted in the authors’ centre between May 2004 and August 2005 who underwent ovulation induction and IUI. Ninety-six women younger than 37 years with adequate ovarian reserve, and 50 women with diminished ovarian reserve were found. The pregnancy rate and pregnancy rate per cycle in the adequate ovarian reserve group were significantly higher than those of the diminished ovarian reserve group (46.7% versus 25%, P < 0.02; 15.9% versus 7.6%, P < 0.02 respectively). It is concluded that the clomiphene citrate challenge test is a good predictor of low-complexity infertility intervention outcome, and represents an effective tool to establish a prognosis. Therefore, it is very useful in planning therapy, and advising the infertile couple.
ISSN:1472-6483
1472-6491
DOI:10.1016/S1472-6483(10)61994-3