Evaluation of antimicrobial activity of β-lactam antibiotics by Etest against clinical isolates from 100 medical centers in Japan (2004)

This antimicrobial resistance surveillance study was performed in 100 medical centers. The susceptibility of 9347 strains including Escherichia coli (997 strains), Klebsiella spp. (997 strains), Enterobacter spp. (988 strains), Citrobacter spp. (834 strains), indole-positive Proteae spp. (855 strain...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2006-06, Vol.55 (2), p.143-148
Main Authors: Ishii, Yoshikazu, Alba, Jimena, Kimura, Soichiro, Yamaguchi, Keizo
Format: Article
Language:English
Subjects:
Acinetobacter
Anti-Bacterial Agents - pharmacology
beta-Lactam Resistance
beta-Lactams - pharmacology
Biological and medical sciences
Citrobacter
Drug resistance
Enterobacter
Escherichia coli
Etest
Fundamental and applied biological sciences. Psychology
Gram-Negative Bacteria - drug effects
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - microbiology
Humans
Infectious diseases
Japan - epidemiology
Klebsiella
Medical sciences
Microbial Sensitivity Tests
Microbiology
Pseudomonas aeruginosa
Reagent Strips
Serratia
Staphylococcus aureus
Susceptibility
β-Lactams
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Summary:This antimicrobial resistance surveillance study was performed in 100 medical centers. The susceptibility of 9347 strains including Escherichia coli (997 strains), Klebsiella spp. (997 strains), Enterobacter spp. (988 strains), Citrobacter spp. (834 strains), indole-positive Proteae spp. (855 strains), Serratia spp. (925 strains), Acinetobacter spp. (902 strains), Pseudomonas aeruginosa (996 strains), oxacillin-susceptible Staphylococcus aureus (992 strains), and coagulase-negative staphylococci (861 strains) to 7 β-lactam antibiotics, cefepime, cefpirome, ceftazidime, cefoperazone/sulbactam, imipenem and piperacillin (for Gram negatives), or oxacillin (for Gram positives) was tested. No strain resistant to these β-lactams except for ceftazidime was found in oxacillin-susceptible S. aureus and coagulase-negative staphylococci. E. coli (16.5%) clinical isolates were resistant to piperacillin, whereas 1.5% or less (cefpirome = 1.5%) was resistant to other β-lactams. Klebsiella spp. strains were more susceptible to imipenem (99.7%), cefepime (98.4%), and cefpirome (97.3%). Isolates of Enterobacter spp., Citrobacter spp., indole-positive Proteae, and Serratia spp. were susceptible to imipenem, cefepime, and cefpirome, as well. Acinetobacter spp. strains were most susceptible to cefoperazone/sulbactam (0.8% resistance), imipenem (3.2%), ceftazidime (6.0%), and cefepime (7.0%) than other β-lactam antibiotics tested. Isolates of P. aeruginosa were more susceptible to ceftazidime (9.9% resistance), cefoperazone/sulbactam (14.9%), and cefepime (11.2%) than piperacillin (15.5%), cefpirome (19.1%), and imipenem (19.3%). The percentage of imipenem-resistant P. aeruginosa is around 20% in clinical isolates in Japan.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2006.01.001