Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma

Peroxiredoxins (Prxs) 1–6 were assessed in 138 renal cell carcinomas (RCC) using immunohistochemistry and selected samples by Western blotting analysis. Oxidative/nitrosative damage was evaluated using nitrotyrosine immunoreactivity. The expressions of Prxs were correlated with tumor grade and survi...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2006-05, Vol.114 (5), p.329-337
Main Authors: SOINI, Y., KALLIO, J. P., HIRVIKOSKI, P., HELIN, H., KELLOKUMPU-LEHTINEN, P., KANG, S. W., TAMMELA, T. L. J., PELTONIEMI, M., MARTIKAINEN, P. M., KINNULA, V. L.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - analysis
Blotting, Western
cancer
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Fundamental and applied biological sciences. Psychology
Humans
Immunohistochemistry
Infectious diseases
kidney
Kidney Neoplasms - diagnosis
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Medical sciences
Microbiology
Middle Aged
Neoplasm Staging
Nephrectomy
Oxidative damage
Oxidative Stress
Peroxidases - analysis
Peroxidases - metabolism
Peroxiredoxins
Prognosis
Survival Analysis
Tumors
Tyrosine - analogs & derivatives
Tyrosine - analysis
Tyrosine - metabolism
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Summary:Peroxiredoxins (Prxs) 1–6 were assessed in 138 renal cell carcinomas (RCC) using immunohistochemistry and selected samples by Western blotting analysis. Oxidative/nitrosative damage was evaluated using nitrotyrosine immunoreactivity. The expressions of Prxs were correlated with tumor grade and survival and nitrotyrosine reactivity. Non‐malignant kidney tubular cells showed positivity with variable intensity for all six Prxs. In RCCs, most cases were positive for Prxs 1 and 2, while only 15–20% of tumors showed expression for Prxs 3 and 4. Prx 2 was associated with tumors of a lower grade (p=0.009) and with a lower frequency of distant metastases (p=0.046). Patients with tumors expressing Prx2 had better prognosis (p=0.027). Instead, nitrotyrosine was significantly associated with high grade tumors (p=0.001). Compared with the non‐malignant kidney tubular cells, low Prx expression in the tumor cells can make them more susceptible to oxidative damage. Prx 2 was more abundantly expressed in low grade tumors, suggesting that this protein could play a role in preventing the development of oxidative damage, which in turn can lead to the activation of pathways leading to aggressive tumors.
ISSN:0903-4641
1600-0463
DOI:10.1111/j.1600-0463.2006.apm_315.x