Evaluation of potential risk factors for early infectious complications after autologous peripheral blood stem cell transplantation in patients with lymphoproliferative diseases

A number of risk factors for the occurrence of neutropaenic fever after haematopoietic stem cell transplantation (HSCT) have been proposed. We were interested in whether these factors remain valid for several early infection-related outcomes when applied to a homogeneous group of patients in uni- an...

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Bibliographic Details
Published in:Annals of hematology 2005-08, Vol.84 (8), p.532-537
Main Authors: Auner, H W, Zebisch, A, Ofner, P, Sill, H, Linkesch, W, Krause, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Analysis of Variance
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Drug therapy
Female
Fever - etiology
Humans
Lymphoproliferative Disorders - complications
Lymphoproliferative Disorders - therapy
Male
Middle Aged
Neutropenia
Opportunistic Infections - etiology
Peripheral Blood Stem Cell Transplantation - adverse effects
Risk Factors
Stem cells
Transplantation Conditioning - adverse effects
Transplantation, Autologous
Transplants & implants
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Summary:A number of risk factors for the occurrence of neutropaenic fever after haematopoietic stem cell transplantation (HSCT) have been proposed. We were interested in whether these factors remain valid for several early infection-related outcomes when applied to a homogeneous group of patients in uni- and multivariate analyses. Therefore, we analysed 144 consecutive patients with lymphoproliferative disorders receiving autologous peripheral blood HSCT. Variables tested as potential risk factors for the occurrence of fever, documented infection (DI), microbiologically documented infection (MDI) or failure of first-line antimicrobial therapy were sex, conditioning regimen, prolonged neutropaenia, low number of CD34+ cells transplanted, purging, lack of selective gut decontamination, higher age and increased body mass index. In uni- and multivariate analyses, conditioning including total body irradiation was the only risk factor for the occurrence of fever, and neutropaenia >or=10 days was the only factor associated with failure of first-line antimicrobial therapy. None of the variables tested was associated with an increased risk for DI or MDI. This analysis suggests that a number of previously proposed risk factors actually are of minor clinical relevance for early infections in the majority of patients receiving autologous HSCT.
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-005-1025-5