Fluorodeoxyglucose positron emission tomography with sentinel lymph node biopsy for evaluation of axillary involvement in breast cancer

Background: This study analysed the value of [18F]fluorodeoxyglucose positron emission tomography (FDG‐PET) in detecting axillary lymph node involvement in women with breast cancer. Methods: In the first 150 women in this prospective study, axillary lymph node dissection (ALND) was performed regardl...

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Bibliographic Details
Published in:British journal of surgery 2006-06, Vol.93 (6), p.707-712
Main Authors: Gil-Rendo, A., Zornoza, G., García-Velloso, M. J., Regueira, F. M., Beorlegui, C., Cervera, M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Axilla - diagnostic imaging
Axilla - pathology
Biological and medical sciences
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
False Negative Reactions
Female
Fluorodeoxyglucose F18
General aspects
Gynecology. Andrology. Obstetrics
Humans
Lymph Node Excision - methods
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Lymphatic Metastasis - diagnostic imaging
Mammary gland diseases
Medical sciences
Middle Aged
Positron-Emission Tomography - methods
Predictive Value of Tests
Prospective Studies
Radiopharmaceuticals
Regression Analysis
Sensitivity and Specificity
Sentinel Lymph Node Biopsy - methods
Tumors
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Summary:Background: This study analysed the value of [18F]fluorodeoxyglucose positron emission tomography (FDG‐PET) in detecting axillary lymph node involvement in women with breast cancer. Methods: In the first 150 women in this prospective study, axillary lymph node dissection (ALND) was performed regardless of the PET results. In a second group (125 women) FDG‐PET was complemented with sentinel lymph node biopsy (SLNB) only in those who did not have pathological axillary uptake. Results: The sensitivity and specificity of FDG‐PET in detecting axillary involvement was 84·5 and 98·5 per cent respectively in the whole series of 275 patients, with two false‐positive and 22 false‐negative results. False‐negative results were associated with some intrinsic tumour characteristics. In 21 women, PET revealed pathological uptake, suggesting involvement of the internal mammary lymph node chain. Whole‐body PET identified a second synchronous tumour in five asymptomatic patients and haematogenous metastases in two patients. Conclusion: The high positive predictive value of PET (98·4 per cent) suggests that FDG uptake in the axilla could be an indication for full ALND without previous SLNB. Copyright © 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Can help direct axillary surgery
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5338