Immunological Response to Highly Active Antiretroviral Therapy in Children with Clinically Stable HIV-1 Infection

We studied changes in 60 immunological parameters after the administration of highly active antiretroviral therapy (HAART) in 192 clinically stable antiretroviral drug–experienced HIV-1–infected children 4 months–17 years old. The studied immunological parameters included standard lymphocyte subsets...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2005-08, Vol.192 (3), p.445-455
Main Authors: Rosenblatt, Howard M., Stanley, Kenneth E., Song, Lin Y., Johnson, George M., Wiznia, Andrew A., Nachman, Sharon A., Krogstad, Paul A.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - immunology
AIDS
Antigens, CD - blood
Antiretroviral Therapy, Highly Active
Antiretrovirals
Biological and medical sciences
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes - immunology
Child
Flow Cytometry
Fundamental and applied biological sciences. Psychology
Highly active antiretroviral therapy
HIV 1
HIV Infections - drug therapy
HIV Infections - immunology
HIV/AIDS
HLA-DR Antigens - blood
Human immunodeficiency virus 1
Human viral diseases
Humans
Immunology
Infections
Infectious diseases
Lymphocyte Activation
Lymphocyte Count
Lymphocytes
Medical sciences
Microbiology
Miscellaneous
Pediatrics
RNA
T lymphocytes
T-Lymphocytes - immunology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Virology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied changes in 60 immunological parameters after the administration of highly active antiretroviral therapy (HAART) in 192 clinically stable antiretroviral drug–experienced HIV-1–infected children 4 months–17 years old. The studied immunological parameters included standard lymphocyte subsets and lymphocyte surface markers of maturation and activation. The most significant changes during the 48-week study period were seen for CD8+, CD8+CD62L+CD45RA+, CD8+CD38+HLA-DR+, and CD4+ T cell percentages (P
ISSN:0022-1899
1537-6613
DOI:10.1086/431597