Structural Characterization of Self-Assembled Monolayers of Neoglycoconjugates Using Atomic Force Microscopy

Thiolated self-assembled monolayers of carbohydrates may serve as useful polyvalent tools to mimic the organized presentation of such molecules at the cell surface. SAMs presenting the disaccharide maltose as a neoglycoconjugate were produced, and the structure was studied by high resolution atomic...

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Bibliographic Details
Published in:Langmuir 2005-07, Vol.21 (14), p.6142-6144
Main Authors: Tromas, Christophe, Eaton, Peter, Mimault, Jean, Rojo, Javier, Penadés, Soledad
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
General and physical chemistry
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Summary:Thiolated self-assembled monolayers of carbohydrates may serve as useful polyvalent tools to mimic the organized presentation of such molecules at the cell surface. SAMs presenting the disaccharide maltose as a neoglycoconjugate were produced, and the structure was studied by high resolution atomic force microscopy. The molecules form highly ordered structures on a gold (111) surface, with lattice parameters determined by the linker moiety rather than the headgroup.
ISSN:0743-7463
1520-5827
DOI:10.1021/la050051f