Sleep disturbance in mild to moderate Alzheimer's disease

To determine the prevalence of sleep disturbance in a memory clinic population of Alzheimer's disease (AD) patients and identify its clinical correlates. Data from 215 attendees at a memory clinic, who were diagnosed with Alzheimer's disease, were examined. This included data from cognitiv...

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Bibliographic Details
Published in:Sleep medicine 2005-07, Vol.6 (4), p.347-352
Main Authors: Moran, Maria, Lynch, C.A., Walsh, C., Coen, R., Coakley, D., Lawlor, B.A.
Format: Article
Language:English
Subjects:
Aged
Aggression
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer's disease
BEHAVE-AD
Caregiver burden
Caregivers
Cognition Disorders - diagnosis
Cost of Illness
Dementia
Female
Humans
Male
Neuropsychological Tests
Prevalence
Severity of Illness Index
Sleep disturbance
Sleep Wake Disorders - diagnosis
Sleep Wake Disorders - epidemiology
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Summary:To determine the prevalence of sleep disturbance in a memory clinic population of Alzheimer's disease (AD) patients and identify its clinical correlates. Data from 215 attendees at a memory clinic, who were diagnosed with Alzheimer's disease, were examined. This included data from cognitive, functional and neuropsychological assessments. Sleep disturbance was determined using the question about diurnal rhythm disturbance on the BEHAVE-AD questionnaire. Two groups, with and without sleep disturbance, were compared. Group differences were analysed using univariate analysis and stepwise logistic regression analysis. The prevalence of sleep disturbance in this sample was 24.5%. The BEHAVE-AD ‘aggressiveness’ ( P=0.009) and ‘global rating’ ( P=0.029) (a measure of global impact of behavioural disturbance) were found to be significant predictors of sleep disturbance in AD. Sleep disturbance in AD is associated with other behavioural symptoms, notably aggressiveness. Sleep disturbance in AD has significant impact on the patient and/or caregiver. Consideration of co-morbid behavioural symptoms may aid the clinician in choosing a suitable treatment for sleep disturbance in AD.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2004.12.005