Studies on the Apoptotic Activity of Natural and Synthetic Retinoids:  Discovery of a New Class of Synthetic Terphenyls That Potently Support Cell Growth and Inhibit Apoptosis in Neuronal and HL-60 Cells

New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess...

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Bibliographic Details
Published in:Journal of medicinal chemistry 2005-06, Vol.48 (13), p.4293-4299
Main Authors: Simoni, Daniele, Giannini, Giuseppe, Roberti, Marinella, Rondanin, Riccardo, Baruchello, Riccardo, Rossi, Marcello, Grisolia, Giuseppina, Invidiata, Francesco Paolo, Aiello, Stefania, Marino, Silvia, Cavallini, Sabrina, Siniscalchi, Anna, Gebbia, Nicola, Crosta, Lucia, Grimaudo, Stefania, Abbadessa, Vincenzo, Di Cristina, Antonietta, Tolomeo, Manlio
Format: Article
Language:English
Subjects:
Apoptosis - drug effects
Biological and medical sciences
Cell Division - drug effects
HL-60 Cells
Humans
Indicators and Reagents
Medical sciences
Miscellaneous
Neurons - cytology
Neurons - drug effects
Neurons - physiology
Neuropharmacology
Neuroprotective agent
Pharmacology. Drug treatments
Retinoids - chemical synthesis
Retinoids - chemistry
Retinoids - pharmacology
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Summary:New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm049080y