Soluble CD40L in patients with morbid obesity: significant reduction after bariatric surgery

Background  Morbid obesity is associated with increased cardiovascular morbidity and mortality. Recent studies suggest that soluble CD40 Ligand (sCD40L) may play a pathogenetic role in atherothrombotic complications in cardiovascular disease as well as in inflammation and thrombosis. As morbid obesi...

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Published in:European journal of clinical investigation 2006-06, Vol.36 (6), p.395-401
Main Authors: Schernthaner, G.-H., Kopp, H.-P., Krzyzanowska, K., Kriwanek, S., Koppensteiner, R., Schernthaner, G.
Format: Article
Language:English
Subjects:
Adult
Bariatric surgery
Biological and medical sciences
Biomarkers - blood
Body Mass Index
C-Reactive Protein - metabolism
CD40 Ligand - blood
Chemokine CCL2 - blood
chronic inflammation
Female
Gastroplasty
General aspects
Humans
Inflammation Mediators - blood
Insulin - blood
Insulin Resistance
Linear Models
Male
Medical sciences
Middle Aged
morbid obesity
Obesity, Morbid - blood
Obesity, Morbid - surgery
platelet activation
Postoperative Period
sCD40L
Solubility
Weight Loss
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Summary:Background  Morbid obesity is associated with increased cardiovascular morbidity and mortality. Recent studies suggest that soluble CD40 Ligand (sCD40L) may play a pathogenetic role in atherothrombotic complications in cardiovascular disease as well as in inflammation and thrombosis. As morbid obesity is closely associated with chronic inflammation and insulin resistance (IR), it was of interest to study sCD40L in patients with morbid obesity before and after massive weight loss induced by bariatric surgery. Patients and methods  A total of 34 patients (mean age 40 ± 12 years) with morbid obesity were studied before and 27·2 months after bariatric surgery. High sensitivity assays were used to measure concentrations of fasting sCD40L, monocyte‐chemoattractant‐protein‐1 (MCP‐1) and high‐sensitive C‐reactive protein (hsCRP). To investigate the associations of concentration changes of the parameters studied, differences between pre‐ and post‐operative data were assessed and tested by univariate and multivariate linear regression analysis. Results  After a mean weight loss of 33·1 ± 18·4 kg, circulating sCD40L decreased significantly from (3·7 ± 1·5) ng mL−1 to (2·2 ± 0·7) ng mL−1, (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2006.01649.x