Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: A retrospective study

To evaluate the results of pulsed dose rate brachytherapy (PDR) in SCACC. From 1996 to 2002, 71 patients (pts) with SCACC were treated with PDR brachytherapy. The median age was 61.2 years (35–88), with a sex ratio of 1 M/6.5 F. The TNM classification was: 14 T1, 41 T2, 15 T3 and 1 T4, 52 N0, 13 N1,...

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Published in:Radiotherapy and oncology 2006-04, Vol.79 (1), p.75-79
Main Authors: Bruna, Antoine, Gastelblum, Pauline, Thomas, Laurence, Chapet, Olivier, Bollet, Marc A., Ardiet, Jean-Michel, Gérard, Jean-Pierre, Peiffert, Didier
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Anus Neoplasms - drug therapy
Anus Neoplasms - pathology
Anus Neoplasms - radiotherapy
Brachytherapy
Brachytherapy - methods
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - radiotherapy
Chemotherapy, Adjuvant
Feasibility Studies
Female
Follow-Up Studies
France
Humans
Male
Middle Aged
Pulsed dose rate
Radiotherapy Dosage
Retrospective Studies
Squamous cell anal canal carcinoma
Survival Analysis
Treatment Outcome
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Summary:To evaluate the results of pulsed dose rate brachytherapy (PDR) in SCACC. From 1996 to 2002, 71 patients (pts) with SCACC were treated with PDR brachytherapy. The median age was 61.2 years (35–88), with a sex ratio of 1 M/6.5 F. The TNM classification was: 14 T1, 41 T2, 15 T3 and 1 T4, 52 N0, 13 N1, 3 N2 and 3 N3. All the pts were M0. Treatment started with external beam irradiation to the posterior pelvis (mean dose: 45.5Gy). Forty-seven patients received chemotherapy (neoadjuvant/concomitant or both). After an interval of 2–6 weeks, PDR interstitial brachytherapy was performed. The mean dose was 17.8Gy to the 85% reference isodose of the Paris system. Treatment was interrupted in only one pt. With a median follow-up of 28.5 months, 2-year actuarial overall survival was 90%. Fourteen relapses occurred (four distant, three regional, and seven local). Ten patients developed a grade III complication (Lent Soma scale) and two a grade IV complication (colostomy or abdominal perineal resection for necrosis). PDR appears to be an effective treatment for SCACC. It is capable of reproducing the results usually observed with continuous LDR.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2006.03.013