Effects of subfertility cause, smoking and body weight on the success rate of IVF

BACKGROUND: We investigated the separate and combined effects of smoking and body mass index (BMI) on the success rate of IVF for couples with different causes of subfertility. METHODS: The success rate of IVF was examined in 8457 women. Detailed information on reproduction and lifestyle factors was...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2005-07, Vol.20 (7), p.1867-1875
Main Authors: Lintsen, A.M.E., Pasker-de Jong, P.C.M., de Boer, E.J., Burger, C.W., Jansen, C.A.M., Braat, D.D.M., van Leeuwen, F.E.
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - etiology
Adult
Biological and medical sciences
Body Mass Index
Body Weight
Female
Fertilization in Vitro
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
Infertility - etiology
Infertility - therapy
IVF
live birth rate
Male
Medical sciences
Netherlands
Obesity - complications
Pregnancy
Pregnancy Outcome
smoking
Smoking - adverse effects
subfertility diagnosis
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Summary:BACKGROUND: We investigated the separate and combined effects of smoking and body mass index (BMI) on the success rate of IVF for couples with different causes of subfertility. METHODS: The success rate of IVF was examined in 8457 women. Detailed information on reproduction and lifestyle factors was combined with medical record data on IVF treatment. All IVF clinics in The Netherlands participated in this study. The main outcome measures were live birth rate per first cycle of IVF differentiated for the major predictive factors. RESULTS: For male subfertility the delivery rate per cycle was significantly lower than unexplained subfertility, OR of 0.70 (95% CI 0.57–0.86); for tubal pathology, the delivery rate was slightly lower, OR = 0.86 (95% CI 0.70–1.01). Smoking was associated with a significantly lower delivery rate was slightly lower; for OR = 0.72 (95% CI 0.61–0.84) and a significantly higher abortion rate compared to non-smoking delivery rates of 21.4% and 16.4%, respectively (P=0.02). Women with a BMI of ≥27 kg/m2 had a significantly lower delivery rate, with an OR of 0.67 (95% CI 0.48–0.94), compared with normal weight women (BMI ≥20 and 10 years from age 20 to 30 years. Subfertile couples may improve the outcome of IVF treatment by lifestyle changes.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/deh898