Effect of continuous positive airway pressure versus supplemental oxygen on sleep quality in obstructive sleep apnea : A placebo-CPAP-controlled study

We investigated the short-term effectiveness of continuous positive airway pressure (CPAP) and oxygen in improving sleep quality in patients with obstructive sleep apnea (OSA). Randomized, double-blind, placebo-controlled, parallel study. General Clinical Research Center at a university hospital. Se...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2006-04, Vol.29 (4), p.564-571
Main Authors: LOREDO, José S, ANCOLI-ISRAEL, Sonia, KIM, Eui-Joong, WEON JEONG LIM, DIMSDALE, Joel E
Format: Article
Language:English
Subjects:
Arousal - physiology
Biological and medical sciences
Continuous Positive Airway Pressure - methods
Diseases of the upper aerodigestive tract
Disorders of Excessive Somnolence - diagnosis
Disorders of Excessive Somnolence - epidemiology
Double-Blind Method
Ent and stomatology
Female
Humans
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Oxygen - therapeutic use
Patient Compliance - statistics & numerical data
Polysomnography
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Severity of Illness Index
Sleep
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - drug therapy
Sleep Apnea, Obstructive - therapy
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that cite this one
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Summary:We investigated the short-term effectiveness of continuous positive airway pressure (CPAP) and oxygen in improving sleep quality in patients with obstructive sleep apnea (OSA). Randomized, double-blind, placebo-controlled, parallel study. General Clinical Research Center at a university hospital. Seventy-six patients with untreated OSA. Patients were randomly assigned to 1 of 3 treatments (CPAP, placebo-CPAP, or nocturnal oxygen at 3 L per minute) for 2 weeks. Sleep quality was assessed at baseline and after 1 and 14 days of therapy. Repeated-measures analysis of variance was used to evaluate treatment and time effects, and their interaction. Sixty-three patients completed the protocol. When compared with placebo-CPAP and nocturnal oxygen, CPAP increased rapid eye movement (REM) sleep and significantly reduced stage 1 sleep and the number of stage shifts (p < or = .003). CPAP improved, to within normal limits, the apnea-hypopnea index, total arousal index, and mean oxyhemoglobin saturation (p < or = .001). The effects of CPAP were apparent during the first night of therapy. Oxygen improved only mean nocturnal saturation (p = .009). CPAP had no significant effect on stage 2 sleep or slow-wave sleep. CPAP was associated with an improvement in sleep quality in patients with OSA by consolidating sleep, reducing stage 1 sleep, and improving REM sleep. CPAP was effective in correcting the respiratory and arousal abnormalities of OSA. The effectiveness of supplemental oxygen was limited to oxyhemoglobin desaturation.
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/29.4.564