Cholinergic bronchomotor tone and airway caliber in tetraplegic patients

Case-control study. To evaluate the resting airway caliber in subjects with tetraplegia; to define the participation of cholinergic innervation in this condition; and to determine if baclofen modifies this pattern. A rehabilitation hospital, Brasília, Brazil. We studied 18 tetraplegic patients, with...

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Bibliographic Details
Published in:Spinal cord 2006-05, Vol.44 (5), p.269-274
Main Authors: MATEUS, S. R. M, BERALDO, P. S. S, HORAN, T. A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Airway Resistance - drug effects
Biological and medical sciences
Bronchodilator Agents - therapeutic use
Case-Control Studies
Cerebrospinal fluid. Meninges. Spinal cord
Humans
Injuries of the nervous system and the skull. Diseases due to physical agents
Ipratropium - therapeutic use
Lung Volume Measurements
Male
Medical sciences
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nervous system (semeiology, syndromes)
Neurology
Quadriplegia - drug therapy
Quadriplegia - physiopathology
Reproducibility of Results
Respiratory Function Tests - methods
Traumas. Diseases due to physical agents
Vital Capacity
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Summary:Case-control study. To evaluate the resting airway caliber in subjects with tetraplegia; to define the participation of cholinergic innervation in this condition; and to determine if baclofen modifies this pattern. A rehabilitation hospital, Brasília, Brazil. We studied 18 tetraplegic patients, with complete motor loss between C4 and C8, and 18 healthy control subjects by measuring airway conductance, before and after inhaled ipratropium bromide. At baseline, the pulmonary function parameters revealed mild-to-moderate restrictive impairment in tetraplegic patients as defined by decreases in total lung capacity and predicted percent of slow vital capacity. The average baseline specific airway conductance (sGaw) was less in tetraplegic patients (0.25+/-0.11) than in the control group (0.41+/-0.10 l/s/cm H(2)O) (Por=40% compared with only four of the 18 controls (P
ISSN:1362-4393
1476-5624
DOI:10.1038/sj.sc.3101836