Initial presentation and fatal complications of linear IgA bullous dermatosis in the larynx and pharynx

Two cases of linear IgA bullous dermatosis initially presenting as ulcerative lesions in the larynx and pharynx are reported. It was difficult to diagnose and treat the lesions, but they were finally diagnosed from the histopathological findings of accompanying skin lesion specimens. One of the pati...

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Bibliographic Details
Published in:Journal of laryngology and otology 2005-04, Vol.119 (4), p.314-318
Main Authors: Sato, Katsuro, Hanazawa, Hideyuki, Sato, Yuichiro, Watanabe, Jun, Takahashi, Sugata
Format: Article
Language:English
Subjects:
(RF) Otorhinolaryngology
Aged
Airway Obstruction
Airway Obstruction - etiology
Biological and medical sciences
Blister
Bullous diseases of the skin
Chronic obstructive pulmonary disease, asthma
Dermatology
Fatal Outcome
Humans
Immunoglobulin A
Immunoglobulin A - analysis
Laryngeal Neoplasms - complications
Laryngeal Neoplasms - diagnosis
Larynx
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Pharyngeal Neoplasms - complications
Pharyngeal Neoplasms - diagnosis
Pharynx
Pneumology
Skin Diseases
Skin Diseases, Vesiculobullous - complications
Skin Diseases, Vesiculobullous - diagnosis
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Summary:Two cases of linear IgA bullous dermatosis initially presenting as ulcerative lesions in the larynx and pharynx are reported. It was difficult to diagnose and treat the lesions, but they were finally diagnosed from the histopathological findings of accompanying skin lesion specimens. One of the patients required a tracheostomy due to increased airway stenosis by a laryngeal lesion. Despite general corticosteroid administration this could not be completely resolved, although partial opening of the glottis was observed, and the patient died of accidental tracheostomy tube complications during home care. Although there are no reports of this disease in the otolaryngological field, these rare diseases involving the skin and entire body should be considered in the differential diagnosis of laryngeal and pharyngeal ulcerative lesions, including airway stenosis. Furthermore, simple and safe procedures for relieving airway stenosis should be selected for rare and difficult-to-diagnose airway disease, prior to the final diagnosis.
ISSN:0022-2151
1748-5460
DOI:10.1258/0022215054020458