Ki-67 proliferative marker in lymph node aspirates of patients with non-Hodgkin's lymphoma

Proliferative activity of lymphoma cells was tested by immunocytochemical staining with Ki-67 monoclonal antibody in 63 aspirates of peripheral lymph nodes sampled from patients suffering from non-Hodgkin's lymphoma. Referring to the dominant cell population in nodal aspirates, a rising trend o...

Full description

Saved in:
Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2006, Vol.23 (1), p.83-90
Main Authors: Mihaljevic, B., Nedeljkov-Jancic, R., Cemerikic-Martinovic, V., Babic, D., Colovic, M.
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy, Needle
Female
Humans
Immunohistochemistry
Ki-67 Antigen - analysis
Lymph Nodes - chemistry
Lymphoma, Non-Hodgkin - mortality
Lymphoma, Non-Hodgkin - pathology
Male
Middle Aged
Oncology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Proliferative activity of lymphoma cells was tested by immunocytochemical staining with Ki-67 monoclonal antibody in 63 aspirates of peripheral lymph nodes sampled from patients suffering from non-Hodgkin's lymphoma. Referring to the dominant cell population in nodal aspirates, a rising trend of Ki-67 proliferative marker was noted from the small cells (X = 13.20) and small cells with notched nucleus (X = 43.52) and large cells (X = 79.47) with histopathologic equivalents corresponding to aggressive lymphoma. Statistical testing of the difference in the Ki-67 proliferative marker against demographic and clinical-laboratory characteristics of the studied patients revealed the levels of significance for the performance status, bone marrow infiltration, and albumin serum value. Correlation of cytomorphological and immunocytochemical results was tested against International Prognostic Index (IPI). Statistically significant correlation of Ki-67 with cytomorphology and REAL-immunocytochemical classification of lymphoma was confirmed, but not with the IPI index. In order to determine the prognostic importance of Ki-67 marker, the patients were classified into those with low Ki-67 (
ISSN:1357-0560
1559-131X
1357-0560
DOI:10.1385/MO:23:1:83