Minor Components of Olive Oil Modulate Proatherogenic Adhesion Molecules Involved in Endothelial Activation

The Mediterranean diet reduces the risk of coronary artery disease as a consequence of its high content of antioxidants, namely, hydroxytyrosol (HT) and oleuropein aglycone (OleA), typical of virgin olive oil. Because intercellular and vascular cell adhesion molecules (ICAM-1 and VCAM-1) and E-selec...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2006-05, Vol.54 (9), p.3259-3264
Main Authors: Dell'Agli, Mario, Fagnani, Rossana, Mitro, Nico, Scurati, Samuele, Masciadri, Maura, Mussoni, Luciana, Galli, Germana V, Bosisio, Enrica, Crestani, Maurizio, De Fabiani, Emma, Tremoli, Elena, Caruso, Donatella
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Adhesion Molecules - analysis
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - physiology
E-Selectin - analysis
E-Selectin - genetics
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Fat industries
Food industries
Fundamental and applied biological sciences. Psychology
Gene Expression - drug effects
Humans
Intercellular Adhesion Molecule-1 - analysis
Intercellular Adhesion Molecule-1 - genetics
Iridoids
Olive Oil
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
Plant Oils - chemistry
Plant Oils - pharmacology
Pyrans - pharmacology
RNA, Messenger - analysis
Umbilical Veins - chemistry
Vascular Cell Adhesion Molecule-1 - analysis
Vascular Cell Adhesion Molecule-1 - genetics
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Summary:The Mediterranean diet reduces the risk of coronary artery disease as a consequence of its high content of antioxidants, namely, hydroxytyrosol (HT) and oleuropein aglycone (OleA), typical of virgin olive oil. Because intercellular and vascular cell adhesion molecules (ICAM-1 and VCAM-1) and E-selectin are crucial for endothelial activation, the role of the phenolic extract from extra virgin olive oil (OPE), OleA, HT, and homovanillyl alcohol (HVA) on cell surface and mRNA expression in human umbilical vascular endothelial cells (HUVEC) was evaluated. OPE strongly reduced cell surface expression of ICAM-1 and VCAM-1 at concentrations physiologically relevant (IC50 < 1 μM), linked to a reduction in mRNA levels. OleA and HT were the main components responsible for these effects. HVA inhibited cell surface expression of all the adhesion molecules, whereas the effect on mRNA expression was weaker. These results supply new insights on the protective role of olive oil against vascular risk through the down-regulation of adhesion molecules involved in early atherogenesis. Keywords: Olive oil; proatherogenic adhesion molecules; endothelial activation; ICAM-1; VCAM-1; hydroxytyrosol; oleuropein aglycone; E-selectin
ISSN:0021-8561
1520-5118
DOI:10.1021/jf0529161