Increased serum phosphodiesterase activity in women with pre-eclampsia

To measure the activity of serum phosphodiesterase (PDE) in pre-eclampsia. Case-control study. Nephrology Laboratory and Obstetrics Unit at São Lucas Hospital from Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. Twenty-nine normal and 28 pregnant women with pre-eclampsia...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2006-05, Vol.113 (5), p.577-579
Main Authors: PINHEIRO DA COSTA, B. E, SCOCCO, C, POLI DE FIGUEIREDO, C. E, GUIMARAES, J. A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
Diseases of mother, fetus and pregnancy
Female
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Phosphoric Diester Hydrolases - metabolism
Pre-Eclampsia - enzymology
Pregnancy
Pregnancy. Fetus. Placenta
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Summary:To measure the activity of serum phosphodiesterase (PDE) in pre-eclampsia. Case-control study. Nephrology Laboratory and Obstetrics Unit at São Lucas Hospital from Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. Twenty-nine normal and 28 pregnant women with pre-eclampsia. Serum was collected from women with pre-eclampsia, at the time of diagnosis, and from gestation-matched controls. Circulating PDE activity was assessed by measuring consumption of the substrate thymidine 5'-monophosphate p-nitrophenyl ester and expressed as PDE units/l. Serum PDE Activity. Mean substrate consumption was higher in pre-eclamptic condition (V(max)= 15.8 +/- 1.4 versus 12.7 +/- 0.9 U/L, P= 3.7 x 10(-14)). These data suggest that altered PDE activity may play a role in pre-eclampsia endothelial dysfunction.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2006.00916.x