Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction

Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction Hajime Iwama, Shiro Uemura, Noriyuki Naya, Kei-ichi Imagawa, Yasuhiro Takemoto, Osamu Asai, Kenji Onoue, Satoshi Okayama, Satoshi Somekawa, Y...

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Published in:Journal of the American College of Cardiology 2006-04, Vol.47 (8), p.1559-1567
Main Authors: Iwama, Hajime, Uemura, Shiro, Naya, Noriyuki, Imagawa, Kei-ichi, Takemoto, Yasuhiro, Asai, Osamu, Onoue, Kenji, Okayama, Satoshi, Somekawa, Satoshi, Kida, Yoshitomi, Takeda, Yukiji, Nakatani, Kimihiko, Takaoka, Minoru, Kawata, Hiroyuki, Horii, Manabu, Nakajima, Tamio, Doi, Naofumi, Saito, Yoshihiko
Format: Article
Language:English
Subjects:
Animals
Blood Cell Count
Bone marrow
Cardiology
Case-Control Studies
Coronary Vessels
Endothelial Cells - metabolism
Female
Heart attacks
Humans
Male
Mice
Mice, Inbred C57BL
Middle Aged
Monocytes - pathology
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Myocardium - metabolism
Placenta Growth Factor
Predictive Value of Tests
Pregnancy Proteins - blood
Pregnancy Proteins - genetics
Pregnancy Proteins - metabolism
Recovery of Function
RNA, Messenger - metabolism
Stroke Volume
Vascular endothelial growth factor
Veins & arteries
Ventricular Function, Left
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Summary:Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction Hajime Iwama, Shiro Uemura, Noriyuki Naya, Kei-ichi Imagawa, Yasuhiro Takemoto, Osamu Asai, Kenji Onoue, Satoshi Okayama, Satoshi Somekawa, Yoshitomi Kida, Yukiji Takeda, Kimihiko Nakatani, Minoru Takaoka, Hiroyuki Kawata, Manabu Horii, Tamio Nakajima, Naofumi Doi, Yoshihiko Saito Placental growth factor (PlGF) is a specific ligand for vascular endothelial growth factor receptor-1 that has been shown in animal studies to stimulate wound healing after ischemic tissue injury by activating mononuclear cells and inducing angiogenesis. The clinical significance of PlGF in acute myocardial infarction is not yet known, however. Our study in humans demonstrates that PlGF is rapidly produced within infarct myocardial tissue during the acute phase of myocardial infarction, and then appears to mediate improvement of left ventricular ejection fraction in the chronic phase, probably by activating monocytes and enhancing angiogenesis. Our aim was to investigate cardiac expression of placental growth factor (PlGF) and its clinical significance in patients with acute myocardial infarction (AMI). Placental growth factor is known to stimulate wound healing by activating mononuclear cells and inducing angiogenesis. The clinical significance of PlGF in AMI is not yet known. Fifty-five AMI patients and 43 control subjects participated in the study. Peripheral blood sampling was performed on days 1, 3, and 7 after AMI. Blood was also sampled from the coronary artery (CAos) and the coronary sinus (CS), before and after acute coronary recanalization. Cardiac expression of PlGF was analyzed in a mouse AMI model. In AMI patients, peripheral plasma PlGF levels on day 3 were significantly higher than in control subjects. Plasma PlGF levels just after recanalization were significantly higher in the CS than the CAos, which indicates cardiac production and release of PlGF. Peripheral plasma levels of PlGF on day 3 were negatively correlated with the acute phase left ventricular ejection fraction (LVEF), positively correlated with both acute phase peak peripheral monocyte counts and chronic phase changes in LVEF. Placental growth factor messenger ribonucleic acid expression was 26.6-fold greater in a mouse AMI model than in sham-operated mice, and PlGF was expressed mainly in endothelial cells within the infarct region. Placental g
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2005.11.064