Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects

Aims We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise. Methods and results The cardiac function of 62 normal glucose tolerant subjects, aged 30–40 and divided into normal weight (group 1, n=22, BMI 20–24.9 kg/m2),...

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Bibliographic Details
Published in:European heart journal 2005-06, Vol.26 (12), p.1205-1212
Main Authors: Sasso, Ferdinando C., Carbonara, Ornella, Nasti, Rodolfo, Marfella, Raffaele, Esposito, Katherine, Rambaldi, Pierfrancesco, Mansi, Luigi, Salvatore, Teresa, Torella, Roberto, Cozzolino, Domenico
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Angiocardioscintigraphy
Biological and medical sciences
Body Mass Index
Cardiology. Vascular system
Exercise
Exercise - physiology
Exercise Test
Female
Glucose Clamp Technique
Humans
Hypoglycemic Agents - pharmacology
Insulin
Insulin - pharmacology
Insulin Resistance - physiology
Left ventricular function
Male
Medical sciences
Metabolic diseases
Obesity
Obesity - physiopathology
Stroke Volume - drug effects
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left - drug effects
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Summary:Aims We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise. Methods and results The cardiac function of 62 normal glucose tolerant subjects, aged 30–40 and divided into normal weight (group 1, n=22, BMI 20–24.9 kg/m2), overweight (group 2, n=20, BMI 25–29.9 kg/m2), and obesity (group 3, n=20, BMI 30–35 kg/m2) was evaluated at rest and during dynamic exercise through angiocardioscintigraphy, when on hyperinsulinaemic euglycaemic clamp (test A) and when on normal saline infusion (test B). Left ventricular function at rest was statistically greater (P
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehi271