Hormone levels before and after tubal sterilization

The aim of this study was to determine whether women experience significant luteal phase hormonal changes following interval tubal sterilization. This is a partly randomized, prospective clinical study. This study involved healthy volunteers in an academic research environment. This study involved 1...

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Bibliographic Details
Published in:Contraception (Stoneham) 2006-05, Vol.73 (5), p.507-511
Main Authors: Gentile, Gwen P., Helbig, Donald W., Zacur, Howard, Park, Taesung, Lee, Young Jack, Westhoff, Carolyn L.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Bipolar tubal cauterization
Birth control
Case-Control Studies
Cautery
Estradiol - blood
Estradiol - urine
Estradiol level
Female
Genital system. Reproduction
Gynecology. Andrology. Obstetrics
Hulka clip sterilization
Humans
Laparoscopic tubal sterilization
Luteal Phase - blood
Luteal Phase - urine
Luteal phase hormonal levels
Medical sciences
Other methods of contraception. Sterilization
Pharmacology. Drug treatments
Posttubal sterilization syndrome
Pregnanediol - urine
Progesterone - blood
Progesterone level
Prospective Studies
Sterilization, Tubal - adverse effects
Sterilization, Tubal - instrumentation
Sterilization, Tubal - methods
Surgical Instruments
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Summary:The aim of this study was to determine whether women experience significant luteal phase hormonal changes following interval tubal sterilization. This is a partly randomized, prospective clinical study. This study involved healthy volunteers in an academic research environment. This study involved 118 fertile women seeking tubal sterilization and 57 fertile controls with at least three normal cyclic menstrual periods before entry into the study. The patients were randomized to bipolar cautery or Hulka clip as sterilization methods. Barrier contraception or abstinence was used by controls. The main outcome measures are serum estradiol and progesterone levels and urinary estradiol and pregnanediol levels obtained during the luteal phase before, 1 year and 2 years after sterilization. The women randomized to the bipolar cautery group had higher midluteal progesterone levels measured between Days 5 and 11 postovulation (15.5 ng/mL before sterilization, 14.5 ng/mL at 1 year and 14.5 ng/mL at 2 years) than did the other two groups. The clip group had progesterone levels of 14.1, 12.0 and 12.5 ng/mL at baseline, 1 year and 2 years, respectively, and the control group had levels of 12.0, 11.9 and 11.3 ng/mL for the same periods. Serum estradiol and progesterone and urinary pregnanediol and estradiol were not significantly changed over the 2-year period, nor were there significant differences between the two groups. There were no significant hormonal changes in sterilized women over a period of 2 years when compared with their baseline levels or when compared with unsterilized age-matched controls.
ISSN:0010-7824
1879-0518
DOI:10.1016/j.contraception.2005.12.002