Folate Supplementation During Pregnancy Improves Offspring Cardiovascular Dysfunction Induced by Protein Restriction

Dietary protein restriction in the rat compromises the maternal cardiovascular adaptations to pregnancy and leads to raised blood pressure and endothelial dysfunction in the offspring. In this study we have hypothesized that dietary folate supplementation of the low-protein diet will improve materna...

Full description

Saved in:

Bibliographic Details
Published in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2006-05, Vol.47 (5), p.982-987
Main Authors:	Torrens, Christopher, Brawley, Lee, Anthony, Frederick W, Dance, Caroline S, Dunn, Rebecca, Jackson, Alan A, Poston, Lucilla, Hanson, Mark A
Format:	Article
Language:	eng
Subjects:	Animals Animals, Newborn Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Diet, Protein-Restricted Diseases of mother, fetus and pregnancy Endothelium, Vascular - physiopathology Experimental diseases Female Folic Acid - pharmacology Gynecology. Andrology. Obstetrics Male Medical sciences Pregnancy Pregnancy Complications, Cardiovascular - etiology Pregnancy Complications, Cardiovascular - physiopathology Pregnancy. Fetus. Placenta Rats Rats, Wistar Vasodilation - drug effects Vitamin B Complex - pharmacology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Dietary protein restriction in the rat compromises the maternal cardiovascular adaptations to pregnancy and leads to raised blood pressure and endothelial dysfunction in the offspring. In this study we have hypothesized that dietary folate supplementation of the low-protein diet will improve maternal vascular function and also restore offspring cardiovascular function. Pregnant Wistar rats were fed either a control (18% casein) or protein-restricted (9% casein) diet ±5 mg/kg folate supplement. Function of isolated maternal uterine artery and small mesenteric arteries from adult male offspring was assessed, systolic blood pressure recorded, and offspring thoracic aorta levels of endothelial nitric oxide (NO) synthase mRNA measured. In the uterine artery of late pregnancy dams, vasodilatation to vascular endothelial growth factor was attenuated in the protein-restricted group but restored with folate supplementation, as was isoprenaline-induced vasodilatation (P
ISSN:	0194-911X 1524-4563