SNP in the Adiponectin Gene Is Associated with Decreased Serum Adiponectin Levels and Risk for Impaired Glucose Tolerance

Adiponectin is a plasma protein produced by the adipose tissue. Hypoadiponectinemia has been associated with insulin resistance and several components of the metabolic syndrome (MS): type 2 diabetes, obesity, and dyslipidemia. We investigated whether single nucleotide polymorphisms (SNPs) at positio...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2005-05, Vol.13 (5), p.807-812
Main Authors: González-Sánchez, José L, Zabena, Carina A, Martínez-Larrad, María T, Fernández-Pérez, Cristina, Pérez-Barba, Milagros, Laakso, Markku, Serrano-Ríos, Manuel
Format: Article
Language:English
Subjects:
abdominal fat
adipocytes
Adiponectin
Adult
Aged
blood proteins
BMI
body mass index
Female
Gene Frequency
genes
Genetic Predisposition to Disease
Genotype
Glucose Intolerance - genetics
glucose tolerance
Humans
hyperglycemia
hypoadiponectinemia
impaired glucose tolerance
insulin resistance
Intercellular Signaling Peptides and Proteins - blood
Intercellular Signaling Peptides and Proteins - genetics
leptin
Male
metabolic syndrome
Middle Aged
noninsulin-dependent diabetes mellitus
obesity
overweight
Phenotype
Polymorphism, Single Nucleotide
risk factors
single nucleotide polymorphism
waist-to-hip ratio
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Summary:Adiponectin is a plasma protein produced by the adipose tissue. Hypoadiponectinemia has been associated with insulin resistance and several components of the metabolic syndrome (MS): type 2 diabetes, obesity, and dyslipidemia. We investigated whether single nucleotide polymorphisms (SNPs) at positions 45 and 276 in the adiponectin gene were associated with features of the MS in 747 unrelated Spanish subjects. The G allele of SNP45 and the G/G genotype of SNP276 were associated with impaired glucose tolerance (p = 0.020 and 0.042, respectively). The G/G genotype for SNP276 was associated with lower serum adiponectin levels as compared with the G/T and T/T genotypes (G/G, 10.10 ± 0.24 [micro]g/mL; G/T, 10.98 ± 0.32 [micro]g/mL; T/T, 12.00 ± 0.92 [micro]g/mL; p = 0.015) even after adjustment for sex, age, BMI, waist-to-hip ratio, homeostasis model assessment index, and the degree of glucose tolerance (p = 0.040). We found a significant negative association of circulating adiponectin levels with waist-to-hip ratio (r = -0.42, p < 0.001), sagittal abdominal diameter (r = -0.24, p < 0.001), triglycerides (r = -0.32, p < 0.001), homeostasis model assessment index (r = -0.14, p = 0.001), and uric acid (r = -0.36, p < 0.001) and positive association with high-density lipoprotein-cholesterol (r = 0.41, p < 0.001). Our findings indicate that serum adiponectin levels are associated with several components of the MS. The SNP276 of the adiponectin gene may affect impaired glucose tolerance and hypoadiponectinemia.
ISSN:1071-7323
1930-7381
1550-8528
1930-739X
DOI:10.1038/oby.2005.91