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Endothelial function, insulin action and cardiovascular risk factors in young healthy adult offspring of parents with Type 2 diabetes: effect of vitamin E in a randomized double-blind, controlled clinical trial
Background and aims Endothelial dysfunction, insulin resistance and oxidative stress are believed to be central and associated mechanisms in atherogenesis. We aimed to determine the effect of the antioxidant vitamin E on endothelial function, insulin action and cardiovascular risk markers in young...
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Published in: | Diabetic medicine 2005-06, Vol.22 (6), p.703-710 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background and aims Endothelial dysfunction, insulin resistance and oxidative stress are believed to be central and associated mechanisms in atherogenesis. We aimed to determine the effect of the antioxidant vitamin E on endothelial function, insulin action and cardiovascular risk markers in young healthy adult offspring of parents with Type 2 diabetes.
Methods Healthy, glucose‐tolerant adults (18–38 years), 14 (12 male/2 female) with at least one parent with Type 2 diabetes, and 14 (12 male/2 female) subjects with no family history of diabetes (controls) were studied. Insulin action was assessed by euglycaemic hyperinsulinaemic clamp (1 mU/kg/min). Endothelial function was assessed by forearm blood flow (FBF) responses to intra‐brachial artery infusions of acetylcholine (ACh) (endothelium‐dependent vasodilation), sodium nitroprusside (SNP) (endothelium‐independent vasodilation) and NG‐monomethyl l‐arginine (LNMMA) (nitric oxide synthase inhibition). Thirteen offspring (18–38 years, 11 male/2 female, BMI |
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ISSN: | 0742-3071 1464-5491 |
DOI: | 10.1111/j.1464-5491.2005.01506.x |