Endothelial function, insulin action and cardiovascular risk factors in young healthy adult offspring of parents with Type 2 diabetes: effect of vitamin E in a randomized double-blind, controlled clinical trial

Background and aims  Endothelial dysfunction, insulin resistance and oxidative stress are believed to be central and associated mechanisms in atherogenesis. We aimed to determine the effect of the antioxidant vitamin E on endothelial function, insulin action and cardiovascular risk markers in young...

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Published in:Diabetic medicine 2005-06, Vol.22 (6), p.703-710
Main Authors: McSorley, P. T., Bell, P. M., Young, I. S., Atkinson, A. B., Sheridan, B., Fee, J. P. H., McCance, D. R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
antioxidant
Antioxidants - administration & dosage
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cross-Over Studies
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - drug therapy
Diabetic Angiopathies - genetics
Double-Blind Method
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
endothelium
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Female
Forearm - blood supply
Humans
Insulin - administration & dosage
insulin resistance
Male
Medical sciences
NG-Nitroarginine Methyl Ester - metabolism
Nitric Oxide - metabolism
Pedigree
relatives
Risk Factors
Type 2 diabetes
Vitamin E
Vitamin E - administration & dosage
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Summary:Background and aims  Endothelial dysfunction, insulin resistance and oxidative stress are believed to be central and associated mechanisms in atherogenesis. We aimed to determine the effect of the antioxidant vitamin E on endothelial function, insulin action and cardiovascular risk markers in young healthy adult offspring of parents with Type 2 diabetes. Methods  Healthy, glucose‐tolerant adults (18–38 years), 14 (12 male/2 female) with at least one parent with Type 2 diabetes, and 14 (12 male/2 female) subjects with no family history of diabetes (controls) were studied. Insulin action was assessed by euglycaemic hyperinsulinaemic clamp (1 mU/kg/min). Endothelial function was assessed by forearm blood flow (FBF) responses to intra‐brachial artery infusions of acetylcholine (ACh) (endothelium‐dependent vasodilation), sodium nitroprusside (SNP) (endothelium‐independent vasodilation) and NG‐monomethyl l‐arginine (LNMMA) (nitric oxide synthase inhibition). Thirteen offspring (18–38 years, 11 male/2 female, BMI 
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2005.01506.x