Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition

Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood, puberty, and young adulthood proceeds via multiple convergent and divergent pathways in the human and experimental animal. Emerging ensemble concepts are required to embody independent, parallel, and interacti...

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Bibliographic Details
Published in:Endocrine reviews 2006-04, Vol.27 (2), p.101-140
Main Authors: Veldhuis, Johannes D, Roemmich, James N, Richmond, Erick J, Bowers, Cyril Y
Format: Article
Language:English
Subjects:
Aging
Animals
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Gonadal Steroid Hormones - physiology
Gonadotropin-Releasing Hormone - physiology
Gonadotropins - physiology
Gonads - physiology
Growth - physiology
Growth Hormone - physiology
Human Growth Hormone - secretion
Humans
Hypothalamus - physiology
Insulin - physiology
Insulin-Like Growth Factor Binding Proteins - physiology
Insulin-Like Growth Factor I - physiology
Insulin-Like Growth Factor I - secretion
Insulin-Like Growth Factor II - physiology
Luteinizing Hormone - secretion
Male
Periodicity
Pituitary Gland - physiology
Puberty - physiology
Sex Characteristics
Sexual Maturation - physiology
Vertebrates: endocrinology
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Summary:Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood, puberty, and young adulthood proceeds via multiple convergent and divergent pathways in the human and experimental animal. Emerging ensemble concepts are required to embody independent, parallel, and interacting mechanisms that subserve physiological adaptations and pathological disruption of reproduction and growth. Significant advances in systems biology will be needed to address these challenges.
ISSN:0163-769X
1945-7189
DOI:10.1210/er.2005-0006