Faecal calprotectin in the assessment of Crohn's disease activity

Background: Clinical and laboratory assessment of activity in Crohn's disease (CD) correlate poorly with endoscopic findings. Calprotectin is a calcium-binding protein abundant in neutrophil cytosol, and extremely stable in faeces. Faecal calprotectin (FC) is an excellent surrogate marker of ne...

Full description

Saved in:
Bibliographic Details
Published in:QJM : An International Journal of Medicine 2005-06, Vol.98 (6), p.435-441
Main Authors: Gaya, D.R., Lyon, T.D.B., Duncan, A., Neilly, J.B., Han, S., Howell, J., Liddell, C., Stanley, A.J., Morris, A.J., Mackenzie, J.F.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - analysis
Crohn Disease - diagnosis
Crohn Disease - metabolism
Cross-Sectional Studies
Feces - chemistry
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Leukocyte L1 Antigen Complex - analysis
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Sensitivity and Specificity
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Clinical and laboratory assessment of activity in Crohn's disease (CD) correlate poorly with endoscopic findings. Calprotectin is a calcium-binding protein abundant in neutrophil cytosol, and extremely stable in faeces. Faecal calprotectin (FC) is an excellent surrogate marker of neutrophil influx into the bowel lumen. Aim: To assess whether FC concentration from a spot stool sample reliably detects active inflammation in patients with CD. Design: Cross-sectional comparative study. Methods: Subjects had a previously confirmed diagnosis of CD and were suspected on clinical grounds to be in the midst of a relapse. Thirty-five entered the study; they underwent radiolabelled white cell scanning (WCS) and had a stool sample collected for calprotectin measurement on the same day. A Crohn's disease activity index (CDAI) was also calculated for each. The WCS scans were scored at six standard sites to give a mean total, ‘extent‘, ‘severity’ and ‘combined extent and severity’ scores. Results: FC was significantly and positively correlated with mean total (r = 0.73, p
ISSN:1460-2725
1460-2393
DOI:10.1093/qjmed/hci069