Electrophysiological Indices of Automatic and Controlled Auditory Information Processing in First-Episode, Recent-Onset and Chronic Schizophrenia

Deficits in amplitudes of auditory event-related potentials (ERP) indexing preattentive, automatic (mismatch negativity, MMN) and controlled, attention-dependent (N2, P3) auditory information processing have been well described in chronic schizophrenia. Normal MMN, but deficient N2 and P3 have been...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2006-04, Vol.59 (8), p.762-772
Main Authors: Umbricht, Daniel S.G., Bates, John A., Lieberman, Jeffrey A., Kane, John M., Javitt, Daniel C.
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Adolescent
Adult
Adult and adolescent clinical studies
Attention - physiology
Biological and medical sciences
Chronic Disease
cognition
Contingent Negative Variation - physiology
Educational Status
Electroencephalography - methods
event-related potentials
Evoked Potentials, Auditory - physiology
Female
Follow-Up Studies
Humans
Male
Medical sciences
mismatch negativity
Prospective Studies
Psychiatric Status Rating Scales - statistics & numerical data
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reaction Time - physiology
Retrospective Studies
Schizophrenia
Schizophrenia - physiopathology
Schizophrenic Psychology
Time Factors
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Summary:Deficits in amplitudes of auditory event-related potentials (ERP) indexing preattentive, automatic (mismatch negativity, MMN) and controlled, attention-dependent (N2, P3) auditory information processing have been well described in chronic schizophrenia. Normal MMN, but deficient N2 and P3 have been reported in first-episode patients. No study has investigated these ERPs concurrently in first-episode patients; thus, reported differences in MMN, N2 and P3 generation may reflect differences in patient samples rather than genuine differences in abnormal generation of these ERPs. We recorded MMN, N2 and P3 in 26 first-episode patients, 25 recent-onset patients within 1.5 to 5 years after first admission, 25 chronic patients and 39 healthy controls. Recent-onset and chronic, but not first-episode patients showed reduced MMN. However, among first-episode patients those with low premorbid educational achievement demonstrated significantly reduced MMN. All patient groups showed pronounced N2 deficits and, to a variable extent, abnormalities in P3 generation. Abnormalities in N2 and P3 generation appear to reflect premorbid neuropathology, whereas MMN deficits may index both ongoing disease processes associated with illness progression as well as premorbid neurocognitive impairment. ERPs may provide tools to assess static and progressive neuropathology in schizophrenia. These findings need confirmation in longitudinal studies.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2005.08.030