Left Ventricular Doppler Characteristics in First-Degree Relatives of Patients with Hypertrophic Cardiomyopathy

Left ventricular (LV) diastolic function may be affected early in patients with hypertrophic cardiomyopathy (HCM), regardless of the phenotypic expression of the disease. The aim of the present study was to detect whether LV diastolic performance, evaluated by conventional Doppler echocardiography,...

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Bibliographic Details
Published in:Angiology 2005-05, Vol.56 (3), p.319-322
Main Authors: Efthimiadis, Georgios K., Parharidis, Georgios E., Karvounis, Haralambos I., Papadopoulos, Christodoulos E., Gemitzis, Konstantinos D., Styliadis, Ioannis H., Karoulas, Takis N., Louridas, Georgios E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiomyopathy, Hypertrophic - diagnostic imaging
Cardiomyopathy, Hypertrophic - genetics
Cardiovascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Echocardiography, Doppler
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Pharmacology. Drug treatments
Phenotype
Ultrasonic investigative techniques
Vasodilator agents. Cerebral vasodilators
Ventricular Function, Left - physiology
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Summary:Left ventricular (LV) diastolic function may be affected early in patients with hypertrophic cardiomyopathy (HCM), regardless of the phenotypic expression of the disease. The aim of the present study was to detect whether LV diastolic performance, evaluated by conventional Doppler echocardiography, is impaired in first-degree relatives of patients with phenotypically expressed HCM, who had no clinical, electrocardiographic, or echocardiographic signs of the disease. Twenty-two young adults having the previously described characteristics comprised the study population and 22 sex- and age-matched healthy individuals served as controls. The 2 groups were compared according to several echocardiographic parameters and the following diastolic function indices: peak velocity of E wave, representing early filling; peak velocity of A wave, representing late filling; ratio of peak early to peak late velocity (E/A); deceleration time of E wave; and LV isovolumic relaxation time. Slower deceleration time of transmitral early filling in first-degree relatives of patients with HCM (192 ±31 vs 149 ±31 msec, p
ISSN:0003-3197
1940-1574
DOI:10.1177/000331970505600312