The role of hereditary hemochromatosis in aseptic loosening following primary total hip arthroplasty

Hereditary hemochromatosis (HH) results in increased iron absorption and subsequent deposition in tissue. This condition occurs predominantly in individuals of Northern European and Celtic origin with Ireland having one of the highest allele frequencies in the world. This study examines the hypothes...

Full description

Saved in:
Bibliographic Details
Published in:Journal of orthopaedic research 2005-05, Vol.23 (3), p.542-548
Main Authors: Lunn, J.V., Gallagher, P.M., Hegarty, S., Kaliszer, M., Crowe, J., Murray, P., Bouchier-Hayes, D.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arthroplasty
Arthroplasty, Replacement, Hip - adverse effects
Aseptic loosening
C282Y gene
Case-Control Studies
Female
Ferritins - blood
Hemochromatosis
Hemochromatosis - genetics
Hemochromatosis Protein
Hip
Histocompatibility Antigens Class I - genetics
Humans
Male
Membrane Proteins - genetics
Middle Aged
Mutation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hereditary hemochromatosis (HH) results in increased iron absorption and subsequent deposition in tissue. This condition occurs predominantly in individuals of Northern European and Celtic origin with Ireland having one of the highest allele frequencies in the world. This study examines the hypothesis that homozygosity for either the C282Y or H63D mutations in the HFE gene may be associated with aseptic loosening following total hip arthroplasty (THA). Two groups of individuals were screened for the C282Y and H63D mutations associated with HH. Group 1 were individuals who had undergone primary hip arthroplasty and group 2 were individuals who had undergone revision hip arthroplasty for aseptic loosening. Exclusion criteria included rheumatoid or other inflammatory arthropathies and revision due to causes other than aseptic loosening. Significantly more patients in the revision THA group were homozygous for the C282Y genotype ( P = 0.014). Aseptic loosening occurred earlier in these patients ( P = 0.009), in particular in the patients who had clinical signs of hemochromatosis. No association was seen with the H63D mutation and revision THA. The incidence of HH in the group of primary THA patients was no higher than the background incidence. Patients who require primary THA and who are homozygous for the C282Y mutation have an increased risk of developing aseptic loosening, leading to revision THA. Moreover C282Y homozygosity appears to be associated with earlier aseptic loosening than in individuals without the C282Y mutation.
ISSN:0736-0266
1554-527X
DOI:10.1016/j.orthres.2004.11.004