High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal

Objectives: The risk of malaria infection is increased during pregnancy, and many countries recommend chloroquine prophylaxis in pregnant women, despite Plasmodium falciparum chloroquine resistance. Chloroquine resistance is associated with the pfcrt gene K76T mutation. The aim of this study was to...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2005-05, Vol.55 (5), p.788-791
Main Authors: Bertin, Gwladys, Ndam, Nicaise Tuikue, Jafari-Guemouri, Sayeh, Fievet, Nadine, Renart, Emily, Sow, Sokhna, Le Hesran, Jean-Yves, Deloron, Philippe
Format: Article
Language:English
Subjects:
Adult
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - pharmacology
Antimalarials - therapeutic use
Biological and medical sciences
Chemoprevention
Chloroquine - pharmacology
Chloroquine - therapeutic use
DNA, Protozoan
Drug Resistance
Female
Humans
Infectious Disease Transmission, Vertical - prevention & control
malaria
Malaria, Falciparum - parasitology
Malaria, Falciparum - prevention & control
Medical sciences
Membrane Proteins - genetics
Membrane Transport Proteins
Mutation
Pharmacology. Drug treatments
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - genetics
Plasmodium falciparum - metabolism
Pregnancy
Pregnancy Complications, Infectious - parasitology
Pregnancy Complications, Infectious - prevention & control
Prevalence
Protozoan Proteins
Senegal
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Summary:Objectives: The risk of malaria infection is increased during pregnancy, and many countries recommend chloroquine prophylaxis in pregnant women, despite Plasmodium falciparum chloroquine resistance. Chloroquine resistance is associated with the pfcrt gene K76T mutation. The aim of this study was to compare the prevalence rate of pfcrt T76 mutation in P. falciparum isolates from infected pregnant and non-pregnant individuals from Senegal. Methods: The study was conducted in the rural maternity hospital of Thiadiaye, Senegal, where malaria is seasonal. Sixty-nine P. falciparum isolates from infected women were collected at delivery. These women were part of a cohort study; they were followed from their first antenatal visit and advised to take chloroquine prophylaxis. For each woman, the earliest P. falciparum-infected blood sample was also used. A control group of 49 non-pregnant individuals with asymptomatic P. falciparum infection was enrolled. Results: During pregnancy, prevalence of T76 mutant parasites was higher than in the 49 non-pregnant controls (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dki097