Cutting Edge: Emergence of CD127high Functionally Competent Memory T Cells Is Compromised by High Viral Loads and Inadequate T Cell Help

In this report we have inspected whether difficulties in controlling viral infections negatively impacts the generation of CD127(high) memory T cells. Using both MHC class I and II tetramers we reveal that CD127(low) T cells are not necessarily rapidly deleted but can persist in a pseudoeffector sta...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2005-05, Vol.174 (10), p.5926-5930
Main Authors: Fuller, Michael J, Hildeman, David A, Sabbaj, Steffanie, Gaddis, Dalia E, Tebo, Anne E, Shang, Liang, Goepfert, Paul A, Zajac, Allan J
Format: Article
Language:English
Subjects:
Animals
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
CD8-Positive T-Lymphocytes - pathology
Cell Differentiation - genetics
Cell Differentiation - immunology
Clonal Deletion - genetics
Clonal Deletion - immunology
Epitopes, T-Lymphocyte - immunology
Female
Humans
Immunocompromised Host - genetics
Immunologic Memory - genetics
Immunophenotyping
Interleukin-2 - antagonists & inhibitors
Interleukin-2 - biosynthesis
Lymphocytic Choriomeningitis - immunology
Lymphocytic Choriomeningitis - pathology
Lymphocytic Choriomeningitis - virology
Lymphocytic choriomeningitis virus - immunology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Receptors, Interleukin-7 - biosynthesis
Receptors, Interleukin-7 - physiology
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - pathology
T-Lymphocyte Subsets - virology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - pathology
T-Lymphocytes, Helper-Inducer - virology
Viral Load
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Description
Summary:In this report we have inspected whether difficulties in controlling viral infections negatively impacts the generation of CD127(high) memory T cells. Using both MHC class I and II tetramers we reveal that CD127(low) T cells are not necessarily rapidly deleted but can persist in a pseudoeffector state in which they display the hallmarks of activated effector cells but are functionally inferior. CD127(high) cells can, however, emerge if the infection is contained. We also show that in the absence of CD4 T cell help significant populations of CD127(high) CD8 T cells fail to emerge. Analyses of cytokine-producing activities by both mouse and human CD8 T cells further document that the extended maintenance of T cells in a CD127(low) state has functional consequences which manifest as an impairment of IL-2 production.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.174.10.5926