Molybdenum and tungsten enzymes: the xanthine oxidase family

Mononuclear molybdenum and tungsten are found in the active site of a diverse group of enzymes that, in general, catalyze oxygen atom transfer reactions. Enzymes of the xanthine oxidase family are the best-characterized mononuclear Mo-containing enzymes. Several 3D structures of diverse members of t...

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Bibliographic Details
Published in:Current opinion in chemical biology 2006-04, Vol.10 (2), p.109-114
Main Authors: Brondino, Carlos D, Romão, Maria João, Moura, Isabel, Moura, José JG
Format: Article
Language:English
Subjects:
Binding Sites
Electron Transport
Models, Molecular
Molybdenum - metabolism
Protein Conformation
Tungsten - metabolism
Xanthine Oxidase - antagonists & inhibitors
Xanthine Oxidase - chemistry
Xanthine Oxidase - metabolism
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Summary:Mononuclear molybdenum and tungsten are found in the active site of a diverse group of enzymes that, in general, catalyze oxygen atom transfer reactions. Enzymes of the xanthine oxidase family are the best-characterized mononuclear Mo-containing enzymes. Several 3D structures of diverse members of this family are known. Recently, the structures of substrate-bound and arsenite-inhibited forms of two members of this family have also been reported. In addition, spectroscopic studies have been utilized to elucidate fine details that complement the structural information. Altogether, these studies have provided an important amount of information on the characteristics of the active site and the electron transfer pathways.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2006.01.034