Use of a bioengineered skin equivalent for the management of difficult skin defects after pediatric multivisceral transplantation

Primary wound closure is not always possible after pediatric multi-visceral transplantation because of oversized donor organs and/or intestinal or graft edema. We report our experience evaluating the safety and efficacy of Graftskin (Apligraf, Organogenesis, Canton, Mass), a bioengineered bi-layered...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2005-05, Vol.52 (5), p.854-858
Main Authors: Drosou, Anna, Kirsner, Robert S., Kato, Tomoaki, Mittal, Naveen, Al-Niami, Ahmed, Miller, Barbara, Tzakis, Andreas G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomedical Engineering
Child, Preschool
Dermatology
Duodenum - transplantation
Esophagus - transplantation
Female
Humans
Immunosuppressive Agents - therapeutic use
Infant
Intestines - transplantation
Liver Transplantation
Male
Medical sciences
Organ Transplantation - methods
Pancreas Transplantation
Retrospective Studies
Skin Transplantation - methods
Skin, Artificial
Stomach - transplantation
Wound Healing - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Primary wound closure is not always possible after pediatric multi-visceral transplantation because of oversized donor organs and/or intestinal or graft edema. We report our experience evaluating the safety and efficacy of Graftskin (Apligraf, Organogenesis, Canton, Mass), a bioengineered bi-layered human skin equivalent, for the management of difficult skin abdominal defects after multivisceral transplantation in a pediatric population. A retrospective chart review was performed of pediatric multivisceral transplantation patients who were treated with Graftskin. Adverse events, course of wound reepithelialization, and time for complete closure were recorded. Four patients, 7 to 29 months old, were treated with Graftskin. One patient died because of unrelated reasons. Stimulation of the granulation, reepithelialization, and rapid reduction of the wound surface and depth occurred in the other 3 patients. Complete reepithelialization occurred within 5 months. No adverse events were noted. Graftskin was a successful treatment for difficult abdominal skin defects after liver and multivisceral transplantation in children.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2004.11.069