Labor induction abortion utilizing trilostane, a 3beta-hydroxysteroid dehydrogenase inhibitor

Labor induction abortion in the second trimester is a difficult problem in developing countries because antiprogestins are either not available or unaffordable. When prostaglandins are used alone for labor induction abortion without antiprogestin pretreatment, the induction to delivery interval and...

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Bibliographic Details
Published in:Contraception (Stoneham) 2005-05, Vol.71 (5), p.343-347
Main Authors: le Roux, Paul A, van der Spuy, Zephne M
Format: Article
Language:English
Subjects:
3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors
Abortifacient Agents, Nonsteroidal - administration & dosage
Abortifacient Agents, Steroidal - administration & dosage
Abortion, Induced
Adult
Ambulatory Care - economics
Dihydrotestosterone - administration & dosage
Dihydrotestosterone - analogs & derivatives
Dihydrotestosterone - economics
Drug Administration Schedule
Enzyme Inhibitors - administration & dosage
Female
Humans
Misoprostol - administration & dosage
Pregnancy
Pregnancy Trimester, Second
South Africa
Time Factors
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Summary:Labor induction abortion in the second trimester is a difficult problem in developing countries because antiprogestins are either not available or unaffordable. When prostaglandins are used alone for labor induction abortion without antiprogestin pretreatment, the induction to delivery interval and the treatment failure rate increase. Trilostane, an inhibitor of 3beta-hydroxysteroid dehydrogenase enzyme system, was given to 93 women between 13 and 19 weeks gestation. The trilostane dosage used was 120 mg twice daily for the first 24 h, and then 240 mg twice daily for the next 24 h. The women returned after 48 h for hospital admission. The women were randomized to three different misoprostol regimens: low-dose vaginal group (200 microg every 4 h), high-dose vaginal group (initial dose of 400 microg followed by 200 microg every 4 h) and vaginal-oral group (400 microg vaginally followed by 200 microg orally every 4 h). The median induction to abortion times were 17, 8.3 and 9.4 h, respectively. The latter two groups had significantly shorter induction to delivery times (p
ISSN:0010-7824
1879-0518