Allograft Glomerulitis: Histologic Characteristics to Detect Chronic Humoral Rejection

The aim of this study was to clarify the histopathologic significance of allograft glomerulitis in chronic allograft nephropathy (CAN). Review of our renal allograft biopsy files revealed 140 specimens with CAN among 115 selected patients. They were classified into two groups: one had CAN with glome...

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Bibliographic Details
Published in:Transplantation proceedings 2005-03, Vol.37 (2), p.714-716
Main Authors: Hara, S., Matsushita, H., Yamaguchi, Y., Kawaminami, K., Horita, S., Furusawa, M.
Format: Article
Language:English
Subjects:
ABO Blood-Group System
Adolescent
Adult
Aged
Antibody Formation
Biological and medical sciences
Blood Group Incompatibility
Cadaver
Child
Creatinine - blood
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Glomerulonephritis - pathology
Graft Rejection - immunology
Graft Rejection - pathology
Humans
Isoantibodies - blood
Male
Medical sciences
Middle Aged
Postoperative Complications - pathology
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue Donors
Tissue, organ and graft immunology
Transplantation, Homologous - pathology
Treatment Failure
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Summary:The aim of this study was to clarify the histopathologic significance of allograft glomerulitis in chronic allograft nephropathy (CAN). Review of our renal allograft biopsy files revealed 140 specimens with CAN among 115 selected patients. They were classified into two groups: one had CAN with glomerulitis (group G), and the other was free of this finding (group NG). We evaluated the clinicopathologic parameters as follows: levels of serum creatinine and proteinuria in the biopsy; presence of circulating anti-donor antibodies; allograft failure rate; history of biopsy-proven acute cellular rejection (ACR) and acute humoral rejection (AHR); complications of ACR and chronic rejection (CR); and results of immunofluorescence studies for C4d and HLA-DR. The glomerulitis group showed a significantly greater incidence of CR complications, the presence of circulating anti-donor antibodies, and C4d deposition in peritubular and glomerular capillaries. This group also showed higher levels of serum creatinine and proteinuria, higher graft loss rate, and increased AHR incidence, although the differences were not significant. There was also no statistical significance in the HLA-DR expression on tubular epithelial cells. The present results strongly suggest that humoral factors may play an important role in the progression of glomerulitis in CAN. Therefore, we suspect that glomerulitis in CAN is one of the main histologic markers for CR. The presence of glomerulitis may represent humoral factor–dependent inflammation. It should be considered an important diagnostic criterion for CR in addition to double-contour formation and elastica disruptions with or without subendothelial inflammation (Banff '97).
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2004.11.077