Natural killer cell developmental pathways: a question of balance

NK cells sit at the crossroads of innate and adaptive immunity and help coordinate tumor immunosurveillance and the immune response against pathogens. Balancing signals to NK cell precursors is crucial for their early development, when transcription factors compete to specify the different lymphocyt...

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Bibliographic Details
Published in:Annual Review of Immunology 2006-01, Vol.24 (1), p.257-286
Main Author: Di Santo, James P
Format: Article
Language:English
Subjects:
Animals
Antigens, Surface
Cell Differentiation
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - immunology
Homeostasis
Humans
Immunity, Innate
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Mice
Models, Immunological
Mutation
Receptors, Immunologic - metabolism
Signal Transduction
Transcription Factors - metabolism
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Summary:NK cells sit at the crossroads of innate and adaptive immunity and help coordinate tumor immunosurveillance and the immune response against pathogens. Balancing signals to NK cell precursors is crucial for their early development, when transcription factors compete to specify the different lymphocyte subsets. Despite an elaborate schema for NK cell development and differentiation, several major issues remain to be addressed, such as identifying the sites for NK cell maturation and defining the peripheral NK cell niche.
ISSN:0732-0582
1545-3278
1365-2567
DOI:10.1146/annurev.immunol.24.021605.090700