Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass

Obesity is considered a state of low-grade chronic inflammation, which may favor the development of cardiovascular diseases. Serum amyloid A (SAA) is an acute phase protein synthesized in response to infection, inflammation, injury, and stress. The aim of the present study was to compare the circula...

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Bibliographic Details
Published in:Obesity surgery 2006-03, Vol.16 (3), p.262-269
Main Authors: Gómez-Ambrosi, Javier, Salvador, Javier, Rotellar, Fernando, Silva, Camilo, Catalán, Victoria, Rodríguez, Amaia, Jesús Gil, M, Frühbeck, Gema
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adult
Anastomosis, Roux-en-Y
Female
Gastric Bypass
Humans
Male
Obesity
Obesity, Morbid - blood
Omentum - metabolism
Postoperative Period
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Serum Amyloid A Protein - analysis
Weight control
Weight Loss
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Summary:Obesity is considered a state of low-grade chronic inflammation, which may favor the development of cardiovascular diseases. Serum amyloid A (SAA) is an acute phase protein synthesized in response to infection, inflammation, injury, and stress. The aim of the present study was to compare the circulating concentrations of SAA and the mRNA expression in omental adipose tissue between lean and obese individuals and to analyze the effect of weight loss after gastric bypass. 16 lean volunteers (BMI 20.5 +/- 0.6 kg/m2) and 24 obese patients (BMI 47.0 +/- 1.2 kg/m2) were included in the study. Serum concentrations of SAA were measured by ELISA. In addition, the concentrations of SAA in 18 morbidly obese patients (7 male/11 female; BMI 44.6 +/- 1.9 kg/m2) were measured before and after weight loss following Roux-en-Y gastric bypass (RYGBP). SAA expression in omental adipose tissue was quantified by RT-PCR in biopsies from obese patients undergoing RYGBP and from age-matched lean individuals subjected to Nissen fundoplication. Obese patients exhibited significantly increased circulating SAA concentrations (6.6 +/- 0.5 vs 39.3 +/- 9.1 microg/ml; P
ISSN:0960-8923
1708-0428
DOI:10.1381/096089206776116525