Hyperpolarization of 13C through order transfer from parahydrogen: A new contrast agent for MRI

The order within proton pairs in organic molecules, resulting from hydrogenation with parahydrogen, can be transferred in great part to nearby carbon 13 spins through adequate field manipulations. The molecules with hyperpolarized 13C thus obtained can be used as new contrast agents of high efficien...

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Bibliographic Details
Published in:Magnetic resonance imaging 2005-02, Vol.23 (2), p.153-157
Main Authors: Goldman, Maurice, Jóhannesson, Haukur, Axelsson, Oskar, Karlsson, Magnus
Format: Article
Language:English
Subjects:
Adiabatic
Animals
Carbon Isotopes
Contrast agents
Contrast Media
Field cycling
Guinea Pigs
Magnetic Resonance Imaging
MRI
Parahydrogen-induced polarization
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Summary:The order within proton pairs in organic molecules, resulting from hydrogenation with parahydrogen, can be transferred in great part to nearby carbon 13 spins through adequate field manipulations. The molecules with hyperpolarized 13C thus obtained can be used as new contrast agents of high efficiency in MRI. After a brief presentation of the hydrogenation process and apparatus, in relatively low magnetic field, we describe the procedure of order transfer to the 13C spins through a sudden drop from the initial field to zero field followed by an adiabatic remagnetization. The expected final polarizations in the absence of relaxation are given for several compounds. Finally, we show an example of MR images observed in vivo on animals as an illustration of the contrast capacity of this new method.
ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2004.11.031